Klf4 induction

Author: hlea

August undefined, 2024

WebApr 8, 2024 · KLF4 is a prominent member of this family, and embryonic deletion of KLF4 leads to alterations in skin permeability and postnatal death. ... Gagea M, Li Z, et al. KLF4 Is Essential for Induction ... WebSpecifically, embryoid bodies were generated in a free-floating environment, followed by the induction process, which occurred in adherent conditions. Results ... We identified 39 lncRNAs bound by Klf4, among which we further revealed the 5430416N02Rik promoter is a chromatin interaction hub. Knockout of the 5430416N02Rik locus reduces the ...

KLF4 is a therapeutically tractable brake on fibroblast ... - JCI

WebApr 10, 2024 · KLF4 had been previously identified as an essential factor for pluripotent stem cell development and the induction of aerobic glycolysis [45,46]. Overall, these results confirm that tumor cells can upregulate their glycolytic metabolism at early stages of malignant progression and that microenvironmental stimuli, including hypoxia, may play … WebApr 18, 2024 · In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. switch interface cable

Direct Evidence for Pitavastatin Induced Chromatin Structure

WebMar 7, 2013 · This induction occurred even in the presence of cycloheximide, suggesting that IRF8-ER induces Klf4 without requiring de novo protein synthesis. In contrast, the suppression of an indirect target gene Myc was blocked when cycloheximide was added as previously reported. 20 Taken together, these results suggest that Klf4 is a direct target … WebAug 28, 2013 · Microarray analysis has shown that many keratin genes were upregulated on KLF4 induction, indicating its role in epithelial differentiation. Additionally, KLF4 has been reported to transactivate promoters of epithelial genes including CYP1A1 , laminin α 3A , laminin 1 , keratin 4 , keratin 19 . WebMay 5, 2014 · Binding of MEF2C at kb −148 from the TSS of the KLF4 gene is essential to pitavastatin-mediated KLF4 induction. (A) HUVECs were incubated with 1 µM pitavastatin for 4 hours. As described in Methods, Chromatin immunoprecipitation was performed followed by deep sequencing. switch interface configuration

KLF4 Is Essential for Induction of Cellular Identity Change …

The Kruppel‐like factor KLF4 is a critical regulator of monocyte ...

WebJun 2, 2009 · To identify a chemical replacement for Klf4, NL-MEFs were transduced with a subset of reprogramming factors comprising Oct4, Sox2, and c-Myc (OSM). To obtain the ≈10 9 cells needed to screen large chemical libraries required expansion of OSM-transduced NL-MEFs for 3 passages before screening. WebMay 29, 2024 · Surprisingly, 308 of the 500 genes showed significantly elevated expression after KLF4 WT induction . For example, the expression of RHOC, RAC1, LMO7, and MIDN was up-regulated by induction of KLF4 WT but not R458A . This result suggested that mCpG-dependent KLF4-binding could activate cellular gene transcription and therefore, we … switch in time nesticoWebSep 2, 2010 · KLF4 expression seems to be important for maintenance of B-cell quiescence, and KLF4 was shown to be down-regulated on B-cell activation. 9 Remarkably, inhibition of B-cell proliferation by FOXO transcription factors is associated with KLF4 induction. 10 Nevertheless, the effect of KLF4 in B-cell proliferation is probably complex. A complete ... switch intervlan routing command

"WebInduction of colitis and treatment. ... KLF4 is a zinc finger transcription factor expressed in differentiated epithelial cells of the intestine and is widely involved in the regulation of cell proliferation, differentiation and embryonic development, ... " - Klf4 induction

Klf4 induction

KLF4 Gene - GeneCards KLF4 Protein KLF4 Antibody

WebAug 23, 2024 · KLF siRNA reduced KLF2 and KLF4 gene expression levels under LSS by 79.7% and 69.8%, respectively (Supplementary Fig. 4c ). We note that this still … WebApr 10, 2024 · KLF4 contains an activation domain as well as a repression domain 21 and is therefore able to induce and suppress the transcription of different genes including molecules involved in the regulation of the immune response ( …

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WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis.Among its related pathways are …

WebJul 19, 2024 · Baseline KLF4 expression in fibroblasts outgrown from mouse lungs on day 21 after bleomycin and saline by qPCR analysis (D) and protein densitometry of Western … WebKLF4 is essential for the cellular response to DNA damage. It is required for preventing cell cycle entry into mitosis following γ-irradiation-induced DNA damage, in promoting DNA repair mechanisms and in preventing the irradiated cell from undergoing programmed cell death (apoptosis).

WebSep 3, 2024 · In this Klf4∆Pod murine model of proliferative glomerulopathy, podocyte-specific knockdown of Klf4 induces podocyte loss and triggers PEC activation and … WebNov 19, 2012 · Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis. Using in vivo EC-specific KLF4 overexpression and knockdown murine models, we found that KLF4 induced …

WebKLF4 induction could therefore contribute to the induction and progression of the disease by upregulating BMP6. KLF4 can also induce EndMT by binding directly to the promoters of some EndMT markers (Sca1 and Fsp1). Intriguingly, the promoter regions of the EndMT markers that showed a higher binding affinity for KLF4 are surrounded by putative ...

WebApr 8, 2024 · In p53-mutated TNBC cells, inhibition of KLF4 by RNA interference reduced NOXA expression. Furthermore, treatment of TNBC cells with a KLF4-inducing small compound, APTO-253, resulted in the induction of NOXA expression and … switch internet 5 portasWebNov 24, 2024 · For the first set of reprogramming experiments, the TF combination known as OSKM—Oct4, Sox2, Klf4, and c-Myc—was used . However, Oct4 is associated with cervical cancer, Sox2 is highly expressed in melanoma cells, Klf4 and c-Myc are involved in cell proliferation, and c-Myc is also a well-known protooncogene. switch internet providers every yearWebMar 14, 2016 · KLF4 induces ductal but represses acinar identity in pancreatic acinar cells • KLF4 is required for acinar-to-ductal cell reprogramming • Mutant KRas, injury, and stress … switch internet provider promotionWebThe KLF4 induction of the iNOS promoter is mediated, in part, through two KLF DNA-binding sites that are adjacent to the proximal NF-κB site and through a cooperative interaction with the NF-κB family member p65. Because KLF4 interacts with the C terminus of p300 and p65 interacts with the N terminus of p300, both KLF4 and p65 may help ... switch interface vlan bindingWebDec 26, 2024 · The rapid induction of Klf4 expressions by LH was observed in preovulatory GCs. To evaluate whether Klf4 affects GC proliferation and survival, primary rat GCs were isolated from pregnant mare serum gonadotropin-primed Sprague–Dawley rat ovaries and transfected with a Klf4 expression vector or Klf4 -specific siRNA, followed by … switch interview nhkWebKlf4. Klf4 encodes Krueppel-like factor 4 (Klf4), a zinc finger transcription factor that is evolutionarily conserved from flies to humans. Klf4 is reported to be expressed in the … switch in time to save nineWebLoss and gain of function experiments demonstrate that the down-regulation of Klf4 expression is required for the induction of EMT in vitro and for metastasis in vivo. In addition, reduced Klf4 expression correlates with shorter disease-free survival of subsets of breast cancer patients. switch into glide the kings