Cisplatin salt wasting

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WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head ... both water restrictions and sodium supplementation may be … WebDec 10, 2024 · A 20-year-old man developed renal salt wasting syndrome (RSWS) during treatment with cisplatin for germ cell testicular cancer. The man had non-seminomatous …

Renal Salt-Wasting Syndrome in a Patient With Cisplatin-Induced ...

WebRenal salt wasting: urine Na will be high. Causes include salt-wasting nephropathy, adrenal insufficiency, cisplatin, and thiazide diuretic use. Euvolemic: Hypothyroidism: check TSH. Glucocorticoid deficiency: check AM cortisol. WebFeb 16, 2024 · Cisplatin Carboplatin 11% (carboplatin likely lower) SIADH, renal salt wasting (tubular damage) Cyclophosphamide Ifosfamide 9%–52% SIADH BCR-ABL tyrosine kinase inhibitors Imatinib 9%–13% SIADH BRAF and VEGF tyrosine kinase inhibitors Axitinib Sorafenib Brivanib Pazopanib Sunitinib 16%–39% SIADH EGFR … graham field patriot hospital bed

Cisplatin-Induced Renal Salt Wasting Requiring over 12 Liters …

WebContact ASN. 1401 H St, NW, Ste 900, Washington, DC 20005. [email protected]. 202-640-4660 WebMar 1, 2024 · Cisplatin may produce renal salt wasting causing symptomatic orthostatic hypotension and hyponatremia associated with abnormalities of the renin-aldosterone … WebCisplatin is an intercalating agent that induces apoptosis of cancer cells, and it has been the most widely used drug in the first-line chemotherapy. However, the increase in cisplatin-resistant cancer cells has become a major obstacle in clinical management of cancers (Amable, 2016 ). graham filler michigan rep

Profound hyponatremia and dehydration: A case of cisplatin …

Cisplatin nephrotoxicity - UpToDate

WebMay 19, 2024 · Rarely, cisplatin-related hyponatremia may result from Renal Salt Wasting Syndrome ( 33 ). Hypernatremia can also develop with cisplatin due to acquired nephrogenic diabetes insipidus with ensuing … WebNov 1, 2003 · In 1988, Hutchison et al reported profound urinary sodium wasting in 7 of 70 patients treated with cisplatin over an 18- month period in 1 institution. 1 All the patients were men with carcinomas (including 1 patient with SCLC) and presented 2-4 months after starting cisplatin-based therapy with signs of vol- ume depletion, urinary salt wasting ... china geographic diverseWebSIADH, renal salt-wasting syndrome, and salt loss caused by vomiting and/or anorexia, should be diagnosed as accurately as possible in future studies. ... Alhosaini MN, Patel A. Cisplatin-induced renal salt wasting syndrome. South Med J. 2010;103(8):793–799. 5. Raftopoulos H. Diagnosis and management of hyponatremia in cancer patients. graham filler voting record

"WebCisplatin is a well-known chemotherapeutic agent that can be associated with It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular... " - Cisplatin salt wasting

Cisplatin salt wasting

WebRenal salt wasting syndrome has been described in 17 case reports since 1984. It is a rare side effect of cisplatin that manifests with polyuria, hypovolemia, and hyponatremia, and, because of similarities in clinical settings and laboratory values, it is frequently misdiagnosed as a syndrome of inappropriate antidiuretic hormone. WebMar 1, 2024 · Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome.

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WebAug 1, 2024 · Cisplatin (CDDP) is an important anticancer drug. A common side effect of CDDP is renal salt and water-wasting syndrome (RSWS). The origin of RSWS is … WebSalt wasting Cisplatin Azacitidine Syndrome of inappropriate antidiuresis Cyclophosphamide Vincristine Nephrogenic diabetes insipidus Cisplatin Ifosfamide Magnesium wasting Cetuximab, panitumumab Cisplatin Crystal nephropathy Methotrexate Acute interstitial nephritis Anti-CTLA-4 antibody

WebCisplatin-Induced Renal Salt Wasting Requiring over 12 Liters of 3% Saline Replacement Case Rep Nephrol. 2024;2024:8137078. doi: 10.1155/2024/8137078. Epub 2024 May 10. Authors Phuong-Chi Pham 1 , Pavani Reddy 1 , Shaker Qaqish 1 , Ashvin Kamath 1 , Johana Rodriguez 2 , David Bolos 2 , Martina Zalom 2 , Phuong-Thu Pham 3 … WebCisplatin Induced Renal Salt Wasting Syndrome: An Uncommon Diagnostic Distinction Session Information. Fluid, Electrolyte, and Acid-Base Disorders: Case Reports ... and recovery is the rule although recurrence is common. While carboplatin is less toxic, cisplatin has unequivocal superiority in most of the cancers in which it is used, making it ...

WebNational Center for Biotechnology Information WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, …

WebThe possibility of Cisplatin induced renal salt wasting was considered. The patient was started on Fludrocortisone 0.1mg twice daily, oral salt tablets 1g QID, sodium bicarbonate tablets 650mg TID and normal saline at 150ml/h. During his five-day hospital course, his renal parameters steadily improved, and his serum sodium improved from 124 mEq ...

WebCisplatin induced renal salt wasting was considered. The patient was started on Fludrocortisone 0.1 mg twice daily, oral salt tablets 1 g QID, sodium bicarbonate tablets … graham finance youtubeWeb42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high … china geo json githubWebOct 6, 2016 · In the clinical setting, the most common and important manifestation of cisplatin nephrotoxicity is AKI, which can be progressive and even irreversible. Other renal manifestations include hypomagnesaemia, salt wasting, a … china geographic mapWebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head ... both water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38(12 ... china geographie test china geographieWebCisplatin induces both inflammation and vascular injury, which further promotes kidney injury. In addition to AKI, cisplatin causes proximal tubulopathy, salt wasting, loss of urinary concentrating ability, and magnesium wasting. View chapter Purchase book T cells in kidney injury and regeneration Li Li, ... graham financial group lake worthWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … china geographical