Cisplatin bonded to guanine

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August undefined, 2024

WebJan 30, 2013 · In agreement with computational results, the IR characterization of cis- [Pt (NH (3)) (2) (G)Cl] (+) points to a covalent structure where Pt is bound to the N7 atom of … WebNov 19, 2003 · The thermodynamics and kinetics for the monofunctional binding of the antitumor drug cisplatin, cis-diamminedichloroplatinum(II), to a purine base site of DNA …

Hydrogen Bonding and Covalent Effects in Binding of …

WebJan 30, 2013 · In addition to the conventional binding sites of native adenine, complexes with N7-H tautomers have also been considered. In agreement with computational results, the IR characterization of cis- [Pt (NH (3)) (2) (G)Cl] (+) points to a covalent structure where Pt is bound to the N7 atom of guanine. WebThe most favorable position on DNA base to react with cisplatin is the N7 site of deoxyguanosine residue. Cisplatin forms only one covalent bond with DNA at first, … east-west university of bangladesh

Interaction of anticancer drug cisplatin with guanine: density

WebNov 10, 1997 · We propose that cisplatin binding to guanine in DNA leads to a point mutation as the latter is the only change that the nucleic acid could "remember" … WebNov 10, 1997 · We propose that cisplatin binding to guanine in DNA leads to a point mutation as the latter is the only change that the nucleic acid could “remember” … WebDec 23, 2004 · This in turn means that the known stability of cisplatin−guanine complexes cannot be ascribed solely to hydrogen bonding and allows decomposition of total binding … cummings oral surgeon

Hydrogen bonding and covalent effects in binding of cisplatin …

Cisplatin - CHEMISTRY COMMUNITY

WebMay 16, 2008 · Abstract and Figures Solid films of DNA with and without the chemotherapeutic agent cisplatin bonded to guanine were bombarded with electrons of 1, 10, 100, and 60,000 eV causing single and... WebMar 1, 2006 · On the left, cisplatin has formed a crosslink between two neighboring guanine bases, causing the DNA double helix to bend around the site of damage. This … cummings or batesWebSep 24, 2024 · The cisplatin molecule hydrolyzes in the cytoplasm, and acts as a potent electrophilic agent, reacting with nucleic acids and sulfhydryl groups of proteins [14,15]. However, the therapeutic target of this drug is genomic and mitochondrial DNA. cummings orchard

"WebMonoalkylating agents can react only with one 7-N of guanine. Limpet attachment and monoalkylation do not prevent the separation of the two DNA strands of the double helix but do prevent vital DNA-processing enzymes from accessing the DNA. The final result is inhibition of cell growth or stimulation of apoptosis, cell suicide. Examples [ edit] " - Cisplatin bonded to guanine

Cisplatin bonded to guanine

Effect of cisplatin binding on guanine in nucleic acid: an ab initio ...

WebThe bonding energies between Cisplatin and the target molecules were performed. Cisplatin forms the strongest bonds with Guanine and Pyridoxal phosphate (vit.B6). The vibrations of Pt-N7 bond in complexes occur in the low range of frequencies with low intensities. Only in case of nucleobases appeared vibrations of Pt-N 7 in high frequencies. WebDec 23, 2004 · Finally, the effect of platination on the pairing of guanine with cytosine is studied in a similar manner, revealing large redistributions of hydrogen bonding but surprisingly small overall changes in pairing energy. * Author for correspondence. E-mail: [email protected]. Phone: 029 20874950. Fax: 029 20874030. Supporting Information …

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WebDec 1, 2003 · The influence of methionine-containing peptides on the reaction of carboplatin with 5'-guanosine monophosphate: a comparison with cisplatin J Inorg Biochem . 2003 … WebIt has bond angles of 90 °. Cisplatin has two chloride ions and two ammonia molecules as ligands. The overall charge on cisplatin is zero, this is because the charge on the ... in cisplatin is replaced by a nitrogen atom on a guanine base, which forms a bond with the platinum ion in cisplatin. Oxaliplatin is another platinum based anticancer ...

Web(a) The structure of cisplatin (with platinum shown in green and nitrogen ligands shown in blue) coordinated to a dinucleotide containing two guanines. Notice the destacking of … WebNov 10, 1997 · We propose that cisplatin binding to guanine in DNA leads to a point mutation as the latter is the only change that the nucleic acid could “remember” after replication. Two ways of producing the point mutation are examined.

WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, … WebDec 7, 2024 · When it binds to the guanine base on the DNA molecule, a chlorine is released from cisplatin and binds to a lone pair on the guanine. Since there are two …

WebDec 1, 2003 · When adenine binds, only a weak hydrogen bond forms between the chloride ligand of cisplatin and the H (2)N-C6 group of adenine. Second, a significantly stronger molecular orbital interaction...

WebJan 24, 2005 · Ab initio and density functional calculations are employed to investigate the role of hydrogen bonding in the binding of cisplatin to the purine bases guanine and … cummings opinionWebPart 1: exploring the structure of cisplatin. Cisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to … cummings o sweet spontaneousWebCircle two atoms on the guanine that cisplatin could bind to. d) Explain two possible ways that cisplatin B can bind to the guanine, using either the chloride ligand or the water ligand. i) Chloride ii) Water 2. There are two possible ways that cisplatin can bind to a DNA molecule, either to two different guanines on cummings orthoWebThe anticancer drug cisplatin operates by reacting with the guanine in DNA. Figure 1 shows a small part of a single strand of DNA. Some lone pairs are shown. Figure 1 3 (a) €€€€The DNA chain continues with bonds at X and Y. State the name of the sugar molecule that is attached to the bond at X. cummings ortho chicoWebPart 1: exploring the structure of cisplatin Cisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to bind to a … east west ventures sdn bhdWebApr 13, 2016 · Five moieties are coordinated by the N7-atoms of guanine bases at positions G1300 of the 16S rRNA and G27, G425, A1606, G2220, G2221 of the 23S rRNA (Figure 1, Supplementary Figure S1). One cisplatin moiety is coordinated by the N-terminus of the ribosomal protein L9 (Figure 1I). A small total number of the cisplatin binding sites in the ... east west ventures east-west university login