Cinnamic acid inhibition cancer cells
WebBackground & objective: Recently, the research showed that cinnamic acid (CINN) could inhibit some cancer cells. This study was designed to investigate the effects of alpha … WebSep 25, 2013 · Interestingly, cinnamic acid also exhibits anti-cancer activity in the cancer stem cells. Huang et al. (2012)examined the effect of cinnamic acid in lung cancer stem cells....
Cinnamic acid inhibition cancer cells
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WebMar 10, 2024 · Two possible mechanisms were considered [ 17 ]: 1) CA activates the human peroxisome proliferator and nuclear receptor to inhibit oncogene (may be c-myc) amplification and expression of other genes; 2) CA blocks the posttranslational modification of cell growth-regulating proteins, such as certain p21ras protein, that is, preventing … WebOct 21, 2024 · Incubation of human colorectal cancer cells in the presence of cinnamic acid at concentration higher than 10 mM resulted in reduced cell viability (IC50 13.6 mM). ... The mechanism is attributed to the lower expression of some drug resistance proteins, inhibition of cell proliferation, and promotion of apoptosis (Lu et al. 2024).
WebJul 18, 2024 · The antioxidant and biological activities of Physalis peruviana have been reported in extracts of the calyxes, leaves, stems, and merely in fruits. These extracts have been shown to inhibit the growth of different cancer cell lines and exhibit protective effects in liver and other cells, as well as exhibit anti-inflammatory activity. 11,12 Some studies … WebCA treatment increased the levels of lipid peroxidation in Hela and ME-180 cells. Among all the concentrations (30, 40, and 50 μg/ml) tested, 50 μg of CA showed maximum levels of thio-barbituric acid reactive substances (TBARS), CD, and LHP in HeLa and ME-180 cells (Figure 73.5).Pro-oxidant activity of hydroxycinnamic acids on DNA damage and lipid …
WebJan 15, 2009 · Here, we demonstrate that the cinnamon-derived dietary Michael acceptor trans-cinnamic aldehyde (CA) impairs melanoma cell proliferation and tumor growth. … WebNov 1, 2024 · Thus, inhibition of CBR1 can increase the therapeutic effect of DOX. In the present study, we used a group of new synthetized cinnamic acid (CA) derivatives to …
WebFig. 1. Chemical Structure of Cinnamic Acid Derivatives Fig. 2. Growth Inhibition with Cinnamic Acid Derivatives MCF-7 (A and B) and PC-3 (C and D) cells were treated …
WebNov 30, 2024 · The anti-cancer activity of cinnamic acid derivatives was measured according to Madhunapantula et al., 2008 . 0.5 x 10 4 colon (HCT-116 and HCT-15) and … north africas 5 largest citiesWebBackground/aim: Breast cancer is the second leading cause of cancer-related deaths in US, which necessitates constant research for medications with minimal adverse effects. … north africa safariWebNov 30, 2024 · However, treating the colon cancer cells with DHCA for 48h showed much better HDAC inhibitory effect (80% and 77% HDAC inhibition, respectively in HCT116 … how to renovate old rvWebJul 24, 2010 · Conclusion: Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFkappaB and AP1 … north africa sasWebTo design & optimize trans-cinnamic acid loaded PLGA nanoparticles & assess its inhibitory effect on epithelial-mesenchymal transition triple-negative BC. ... the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer . Fulltext; Metrics; Get Permission; Cite this article; how to renovate kitchen worktopsWebCinnamic acid containing an aryl ring with α, β-unsaturated ketone, was reported to have anticancer activity. Therefore, both chalcone and cinnamic acid have been adapted as versatile structural moieties in many cases of cancer drug development [ 30 ]. how to renovate villagers homesWebThe potential of cinnamic acid as an anti-inflammatory and anti-cancer agent has been studied previously. In our investigation, novel bio-isosters of cinnamyl sulfonamide hydroxamate were synthesized, characterized and confirmed for their structure and evaluated for cytotoxicity. ... -2 and -3 showed cell-growth inhibition in 6 human cancer ... how to renovate vintage rv